ISSN : 2395-552X

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ABSTRACT

Safety Concerns and Pharmacovigilance Insights in Pain Management for Fracture Patients

Zhang Guo, Jiang Zhu

ABSTRACT

Background: Analgesic medications, while effective for pain relief, are associated with a range of side effects from mild discomfort to severe complications. Following surgical repair of fractures, analgesics are routinely prescribed, yet data on their adverse events specifically in ankle and hind foot fractures remain limited. This study aims to evaluate patterns of oral analgesic prescriptions post-surgery for these fractures, document the occurrence of adverse events, and identify potential risk factors. Methods: The study recruited 19 adult patients with traumatic ankle and hind foot fractures at a tertiary care hospital. Prescribed oral analgesics at discharge and at the one-week follow-up were recorded. Potential adverse events were monitored at one- and two-week follow-ups. Incidence rates were calculated, and relationships between adverse events, age, and gender were analyzed using logistic regression and correlation assessments.

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