Monali N. Dumore1*, Nitin G. Dumore2 and Sachin M. Hiradeve3

ABSTRACT

For orally administered drugs, solubility is one of the rates limiting parameter to reach their desired concentration into the systemic circulation for pharmacological response. Among all newly invented chemical entities about 40% drugs are lipophillic and fail to reach market due to their poor water solubility. Problem of solubility is a major challenge for formulation scientist, which can be solved by different technological approaches during the pharmaceutical product development. Various techniques are used for the improvement of aqueous solubility ,dissolution rate, and bioavailability of poorly water soluble drugs include micronization, chemical modification, pH adjustment, solid dispersion, cyclodextrin inclusion complexation ,co-solvency, micellar solubilization, hydrotrophy etc. Some novel techniques like Nano-suspension, Supercritical processing, Cryogenic technology may allow greater opportunities in the delivery of poorly soluble drugs. The water solubility of any drug is determined by its potency and its type of formulation. If a drug is hydrophilic, the dissolved drug molecule will not partition from the aqueous exterior into a lipophilic bio membrane and then permeate the membrane. From many techniques Cyclodextrin having many applications and versatile nature to complexation ability due to this it is mostly useful excipient in pharmaceutical industry for different drug delivery. The purpose of this review is to discuss about the cyclodextrins molecular structure, types and derivatives which is used to enhance the dissolution rate with increase in bioavailability, Poorly water soluble drugs, BCS Class, Complexation technique. Key words: Cyclodextrin, Bioavailability, Water Insoluble Drugs, Complexation techniques, Drug delivery systems